1941
Rosemary Kennedy, who is mentally ill, is institutionalized following a failed lobotomy. The eldest Kennedy daughter of Joseph and Rose, now 80, remains hospitalized.
1944
Joseph P. Kennedy, Jr, the oldest Kennedy son, dies in a plane crash over the English Channel during World War II. The pilot was 29 at the time of his death.
1948
Kathleen Kennedy Cavendish dies in a plane crash in France at age 28. Her husband, William John Robert Cavendish, the Marquess of Hartington, died in World War II.
1963
Patrick Bouvier Kennedy, the second son of President Kennedy and his wife, Jacqueline, dies on August 7, two days after he was born almost six weeks premature.
1963
President John F. Kennedy is assassinated on November 23 in Dallas. He was 46.
1964
Sen. Edward M. Kennedy, the youngest Kennedy child, escapes death in a plane crash that claims an aide, Edward Moss.
1968
Robert F. Kennedy is assassinated on June 5 in Los Angeles. The 42 year old had just won California's Democratic presidential primary election.
1969
Edward M. Kennedy, drives off a bridge on his way home from a party on Massachusetts' Chappaquiddick Island. Mary Jo Kopechne, an aide who was in the car with him, dies in the accident.
1973
Edward M. Kennedy, Jr., the senator's son, loses his right leg to cancer.
1973
Joseph P. Kennedy II, the son of Robert and Ethel, is the driver in a car accident on Cape Cod that leaves one passenger permanently paralyzed.
1984
David A. Kennedy, son of Robert, dies of a drug overdose in a Palm Beach, Florida, hotel. He was 28.
1986
Patrick Kennedy, the teenage son of Sen. Edward Kennedy, undergoes treatment for cocaine addiction.
1988
Christina Onassis, Jacqueline's step-daughter, dies of heart failure related to drug abuse.
1991
William Kennedy Smith, the son of Jean Kennedy Smith, is accused of raping a woman at the family's Palm Beach, Florida, vacation home. He is tried and acquitted.
1997
Michael Kennedy, the son of Robert, dies in a skiing accident in Aspen, Colorado. He was 39. Prior to the accident, Michael made headlines for allegedly having a long-term affair with his children's babysitter.
1999
John F. Kennedy, Jr., his wife and her sister die when JFK, Jr.'s plane crashes into the ocean off the foggy coast of Massachusetts.
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